Question 1

Germ line mutation of E-cadherin is found in familial cases of

Accepted Answer

A)   lymphoblastic lymphoma
B)   Ewing sarcoma
C)   neuroblastoma
D)   gastric carcinoma
E)   seminomaF) C) and E)
G) A) and C)

Question 2

Which enzymes in the liver account for the activation of most procarcinogens into carcinogens?

Accepted Answer

A)   Cytochrome P-450-dependent mono-oxidases
B)   Aminotransferases
C)   Hydroxylases
D)   Glutathione dehydrogenase
E)   CaspasesF) All of the above
G) C) and E)

Question 3

Pseudomyxoma peritonei is a complication of which tumor?

Accepted Answer

A)   Serous cystadenoma of the ovary
B)   Mucinous cystadenoma of the ovary
C)   Ovarian fibroma
D)   Myxoma of the heart
E)   Myxosarcoma of the lower extremityF) All of the above
G) None of the above B

Question 4

Homogeneous staining regions (HSR)  of chromosome 2p, the site of the N-mycgene, are adverse prognostic signs if found in neuroblastoma cells. HRS are evidence of gene

Accepted Answer

A)   deletion
B)   amplification
C)   point mutation
D)   translocation
E)   inversionF) A) and E)
G) None of the above

Question 5

Matrix metalloproteinases secreted by tumor cells are important for which feature of malignant tumors?

Accepted Answer

A)   Desmoplasia
B)   Anaplasia
C)   Invasiveness
D)   Apoptosis
E)   DifferentiationF) C) and D)
G) B) and C)

Question 6

Which one of the following carcinomas is locally invasive but rarely forms metastases in lymph nodes and distant sites?

Accepted Answer

A)   Basal cell carcinoma of the skin
B)   Squamous cell carcinoma of the skin
C)   Oat cell carcinoma of the lung
D)   Transitional cell carcinoma of the urinary bladder
E)   Adenocarcinoma of the stomachF) A) and B)
G) A) and E)

Question 7

Clubbing of the digits, periosteal new bone formation on the metatarsals, metacarpals, and proximal phalanges, and arthritis of adjacent joints is a paraneoplastic syndrome most often associated with carcinoma of the

Accepted Answer

A)   thyroid
B)   larynx
C)   bronchi
D)   liver
E)   stomachF) B) and E)
G) A) and E)

Question 8

Helicobacter pylori infection predisposes to formation of gastric tumors, but the association between the bacterial infection and a gastric tumor is the strongest for

Accepted Answer

A)   adenocarcinoma of the stomach
B)   gastrointestinal stromal tumors
C)   marginal zone lymphomas
D)   T-cell lymphoma
E)   Burkitt lymphomaF) A) and D)
G) A) and C)

Question 9

Germ line mutation of the Von Hippel-Lindau (VHL)  gene is associated with formation of retinal angiomas and

Accepted Answer

A)   glioblastoma multiforme
B)   oligodendroglioma
C)   neurinomas
D)   ependymomas
E)   cerebellar hemangioblastomasF) A) and B)
G) None of the above E

Question 10

Which is the most common radiation-induced cancer in humans?

Accepted Answer

A)   Thyroid cancer
B)   Chronic lymphocytic leukemia
C)   Breast cancer
D)   Lung cancer
E)   Salivary gland carcinomaF) B) and C)
G) B) and E) B

Question 11

Which mechanism affecting the genes or chromosomes accounts for the activation of the c-myc protooncogene in Burkitt lymphoma cells?

Accepted Answer

A)   Overexpression
B)   Amplification
C)   Point mutation
D)   Translocation
E)   Inactivation of its promotorF) A) and B)
G) A) and D)

Question 12

Which of the following tumors occurs most often in the ovary?

Accepted Answer

A)   Chondroma
B)   Hemangioma
C)   Leiomyoma
D)   Transitional cell papilloma
E)   CystadenomaF) A) and B)
G) A) and C)

Question 13

In which cell function is BRCA1, a gene mutated in women with familial breast carcinoma, involved?

Accepted Answer

A)   Cell adhesion
B)   Growth inhibition
C)   Signal transduction
D)   Cell surface channel
E)   Transcriptional regulation and DNA repairF) B) and E)
G) B) and D)

Question 14

Microsatellite instability, a marker of DNA mismatch repair, is typically found in

Accepted Answer

A)   hereditary nonpolyposis colon cancer
B)   familial adenomatous polyposis coli
C)   T-cell lymphoma
D)   B-cell lymphoma
E)   myelogenous leukemiaF) A) and D)
G) A) and B)

Exam 5: Neoplasia

Germ line mutation of E-cadherin is found in familial cases of

Correct Answer
verified

Which enzymes in the liver account for the activation of most procarcinogens into carcinogens?

Correct Answer
verified

Pseudomyxoma peritonei is a complication of which tumor?

Correct Answer
verified
B

Homogeneous staining regions (HSR) of chromosome 2p, the site of the N-mycgene, are adverse prognostic signs if found in neuroblastoma cells. HRS are evidence of gene

Correct Answer
verified

Matrix metalloproteinases secreted by tumor cells are important for which feature of malignant tumors?

Correct Answer
verified

Which one of the following carcinomas is locally invasive but rarely forms metastases in lymph nodes and distant sites?

Correct Answer
verified

Clubbing of the digits, periosteal new bone formation on the metatarsals, metacarpals, and proximal phalanges, and arthritis of adjacent joints is a paraneoplastic syndrome most often associated with carcinoma of the

Correct Answer
verified

Helicobacter pylori infection predisposes to formation of gastric tumors, but the association between the bacterial infection and a gastric tumor is the strongest for

Correct Answer
verified

Germ line mutation of the Von Hippel-Lindau (VHL) gene is associated with formation of retinal angiomas and

Correct Answer
verified
E

Which is the most common radiation-induced cancer in humans?

Correct Answer
verified
B

Which mechanism affecting the genes or chromosomes accounts for the activation of the c-myc protooncogene in Burkitt lymphoma cells?

Correct Answer
verified

Which of the following tumors occurs most often in the ovary?

Correct Answer
verified

In which cell function is BRCA1, a gene mutated in women with familial breast carcinoma, involved?

Correct Answer
verified

Microsatellite instability, a marker of DNA mismatch repair, is typically found in

Correct Answer
verified

Exam 5: Neoplasia

Germ line mutation of E-cadherin is found in familial cases of

Correct AnswerverifiedShow Answer

Which enzymes in the liver account for the activation of most procarcinogens into carcinogens?

Correct AnswerverifiedShow Answer

Pseudomyxoma peritonei is a complication of which tumor?

Correct AnswerverifiedB

Homogeneous staining regions (HSR) of chromosome 2p, the site of the N-mycgene, are adverse prognostic signs if found in neuroblastoma cells. HRS are evidence of gene

Correct AnswerverifiedShow Answer

Matrix metalloproteinases secreted by tumor cells are important for which feature of malignant tumors?

Correct AnswerverifiedShow Answer

Which one of the following carcinomas is locally invasive but rarely forms metastases in lymph nodes and distant sites?

Correct AnswerverifiedShow Answer

Clubbing of the digits, periosteal new bone formation on the metatarsals, metacarpals, and proximal phalanges, and arthritis of adjacent joints is a paraneoplastic syndrome most often associated with carcinoma of the

Correct AnswerverifiedShow Answer

Helicobacter pylori infection predisposes to formation of gastric tumors, but the association between the bacterial infection and a gastric tumor is the strongest for

Correct AnswerverifiedShow Answer

Germ line mutation of the Von Hippel-Lindau (VHL) gene is associated with formation of retinal angiomas and

Correct AnswerverifiedE

Which is the most common radiation-induced cancer in humans?

Correct AnswerverifiedB

Which mechanism affecting the genes or chromosomes accounts for the activation of the c-myc protooncogene in Burkitt lymphoma cells?

Correct AnswerverifiedShow Answer

Which of the following tumors occurs most often in the ovary?

Correct AnswerverifiedShow Answer

In which cell function is BRCA1, a gene mutated in women with familial breast carcinoma, involved?

Correct AnswerverifiedShow Answer

Microsatellite instability, a marker of DNA mismatch repair, is typically found in

Correct AnswerverifiedShow Answer

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B

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E

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B

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